NEUROSCIENCES AND NEUROANAESTHESIA Randomized controlled trial of effects of the airflow through the upper respiratory tract of intubated brain-injured patients on brain temperature and selective brain cooling
نویسندگان
چکیده
Methods. Air at room temperature and humidity was continuously administered to 15 braininjured, intubated and mechanically ventilated patients via a sponge-tipped oxygen catheter in each nostril at a combined rate of 115 ml kg 1 min . Brain temperature was measured using a pressure–temperature Camino catheter which is designed to site the thermistor 1 cm into the parenchyma in the frontal lobe. Oesophageal temperature was measured using an oesophageal stethoscope with a thermistor. After establishing baseline for 30 min, patients were randomized to receive airflow or no airflow for 6 h and then crossed over for a further 6 h.
منابع مشابه
NEUROSCIENCES AND NEUROANAESTHESIA Incidence of adrenal insufficiency after severe traumatic brain injury varies according to definition used: clinical implicationsy
Methods. We retrospectively reviewed the charts of 113 traumatic brain injury patients within 10 days of their injury. They all had a high-dose corticotropin stimulation test performed because of haemodynamic instability. Blood cortisol concentrations were measured at baseline, 30 and 60 min after the administration of high-dose corticotropin. The incidence of adrenal insufficiency was determin...
متن کاملNEUROSCIENCES AND NEUROANAESTHESIA Global field synchrony during general anaesthesia
Editor’s key points † Conscious experience requires ‘cognitive binding’ which integrates multiple current perceptions into a unified experience. † Communication between distant brain regions may be facilitated by long-range synchronization of electrical activity. † Anaesthetic agents may disrupt consciousness by impairing this communication. † The current study investigated the effects of gener...
متن کاملNEUROSCIENCES AND NEUROANAESTHESIA Apoptotic neurodegeneration and spatial memory are not affected by sedative and anaesthetics doses of ketamine/medetomidine combinations in adult mice
Editor’s key points † The combined effect of ketamine and medetomidine on cognition and apoptosis was studied in mice. † No differences were seen between groups in terms of spatial memory or apoptosis. † Hyperlocomotive activity in mice receiving ketamine was attenuated by medetomidine. † Co-administration of ketamine and medetomidine may be clinically useful. Background. Ketamine is increasing...
متن کاملNEUROSCIENCES AND NEUROANAESTHESIA Brain regional vulnerability to anaesthesia-induced neuroapoptosis shifts with age at exposure and extends into adulthood for some regions
Editor’s key points † Pre-clinical studies of various species demonstrate anaesthetic-induced neonatal neurotoxicity. † In the current study, mice of different ages were anaesthetized with isoflurane. † Thereafter, neuroapoptosis was quantified in brain regions which have different age-related time courses of neurogenesis. † Susceptibility to apoptosis appeared to parallel peaks of neurogenesis...
متن کاملNEUROSCIENCES AND NEUROANAESTHESIA Sevoflurane pre- and post-conditioning protect the brain via the mitochondrial KATP channel
Methods. Adult Wistar male rats were subjected to focal cerebral ischaemia for 1 h followed by 24 h or 7 days of reperfusion. Preconditioning consisted of 15 min exposure to sevoflurane at 1 minimum alveolar concentration (2.6%) 72 h before ischaemia. Post-conditioning was performed by exposure to sevoflurane immediately at the onset of reperfusion or by a delayed exposure 5 min after the onset...
متن کامل